Digestive system disease

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Structures and functions of the human digestive system

Digestive System Hands-On Activities – Esophagus, Stomach, Small Intestines

The mouth is surrounded by strong lips, which act like a hand to grab pieces of dead grass, leaves, and weeds, with bits of soil to help chew. The lips break the food down into smaller pieces.

In the pharynx, the food is lubricated by mucus secretions for easier passage. The esophagus adds calcium carbonate to neutralize the acids formed by food matter decay. Temporary storage occurs in the crop where food and calcium carbonate are mixed. The powerful muscles of the gizzard churn and mix the mass of food and dirt. When the churning is complete, the glands in the walls of the gizzard add enzymes to the thick paste, which helps chemically breakdown the organic matter.

By peristalsis , the mixture is sent to the intestine where friendly bacteria continue chemical breakdown. This releases carbohydrates, protein, fat, and various vitamins and minerals for absorption into the body. In most vertebrates , digestion is a multistage process in the digestive system, starting from ingestion of raw materials, most often other organisms.

Ingestion usually involves some type of mechanical and chemical processing. Digestion is separated into four steps:.

Underlying the process is muscle movement throughout the system through swallowing and peristalsis. Each step in digestion requires energy, and thus imposes an "overhead charge" on the energy made available from absorbed substances.

Differences in that overhead cost are important influences on lifestyle, behavior, and even physical structures. Examples may be seen in humans, who differ considerably from other hominids lack of hair, smaller jaws and musculature, different dentition, length of intestines, cooking, etc. The major part of digestion takes place in the small intestine. The large intestine primarily serves as a site for fermentation of indigestible matter by gut bacteria and for resorption of water from digests before excretion.

In mammals , preparation for digestion begins with the cephalic phase in which saliva is produced in the mouth and digestive enzymes are produced in the stomach. Mechanical and chemical digestion begin in the mouth where food is chewed , and mixed with saliva to begin enzymatic processing of starches.

The stomach continues to break food down mechanically and chemically through churning and mixing with both acids and enzymes. Absorption occurs in the stomach and gastrointestinal tract , and the process finishes with defecation. The human gastrointestinal tract is around 9 meters long. Food digestion physiology varies between individuals and upon other factors such as the characteristics of the food and size of the meal, and the process of digestion normally takes between 24 and 72 hours.

Digestion begins in the mouth with the secretion of saliva and its digestive enzymes. Food is formed into a bolus by the mechanical mastication and swallowed into the esophagus from where it enters the stomach through the action of peristalsis.

Gastric juice contains hydrochloric acid and pepsin which would damage the walls of the stomach and mucus is secreted for protection. In the stomach further release of enzymes break down the food further and this is combined with the churning action of the stomach. The partially digested food enters the duodenum as a thick semi-liquid chyme. In the small intestine, the larger part of digestion takes place and this is helped by the secretions of bile , pancreatic juice and intestinal juice.

The intestinal walls are lined with villi , and their epithelial cells is covered with numerous microvilli to improve the absorption of nutrients by increasing the surface area of the intestine. In the large intestine the passage of food is slower to enable fermentation by the gut flora to take place.

Here water is absorbed and waste material stored as feces to be removed by defecation via the anal canal and anus.

Different phases of digestion take place including: The cephalic phase occurs at the sight, thought and smell of food, which stimulate the cerebral cortex. Taste and smell stimuli are sent to the hypothalamus and medulla oblongata. After this it is routed through the vagus nerve and release of acetylcholine. Acidity in the stomach is not buffered by food at this point and thus acts to inhibit parietal secretes acid and G cell secretes gastrin activity via D cell secretion of somatostatin.

The gastric phase takes 3 to 4 hours. It is stimulated by distension of the stomach, presence of food in stomach and decrease in pH. Distention activates long and myenteric reflexes. This activates the release of acetylcholine , which stimulates the release of more gastric juices.

As protein enters the stomach, it binds to hydrogen ions, which raises the pH of the stomach. Inhibition of gastrin and gastric acid secretion is lifted. This triggers G cells to release gastrin , which in turn stimulates parietal cells to secrete gastric acid. Gastric acid is about 0. Acid release is also triggered by acetylcholine and histamine.

The intestinal phase has two parts, the excitatory and the inhibitory. Partially digested food fills the duodenum. This triggers intestinal gastrin to be released. Enterogastric reflex inhibits vagal nuclei, activating sympathetic fibers causing the pyloric sphincter to tighten to prevent more food from entering, and inhibits local reflexes. Protein digestion occurs in the stomach and duodenum in which 3 main enzymes, pepsin secreted by the stomach and trypsin and chymotrypsin secreted by the pancreas, break down food proteins into polypeptides that are then broken down by various exopeptidases and dipeptidases into amino acids.

The digestive enzymes however are mostly secreted as their inactive precursors, the zymogens. For example, trypsin is secreted by pancreas in the form of trypsinogen , which is activated in the duodenum by enterokinase to form trypsin. Trypsin then cleaves proteins to smaller polypeptides. Digestion of some fats can begin in the mouth where lingual lipase breaks down some short chain lipids into diglycerides.

However fats are mainly digested in the small intestine. In humans, dietary starches are composed of glucose units arranged in long chains called amylose, a polysaccharide. During digestion, bonds between glucose molecules are broken by salivary and pancreatic amylase , resulting in progressively smaller chains of glucose.

This results in simple sugars glucose and maltose 2 glucose molecules that can be absorbed by the small intestine. Lactase is an enzyme that breaks down the disaccharide lactose to its component parts, glucose and galactose. Glucose and galactose can be absorbed by the small intestine. Approximately 65 percent of the adult population produce only small amounts of lactase and are unable to eat unfermented milk-based foods.

This is commonly known as lactose intolerance. Lactose intolerance varies widely by ethnic heritage; more than 90 percent of peoples of east Asian descent are lactose intolerant, in contrast to about 5 percent of people of northern European descent.

Sucrase is an enzyme that breaks down the disaccharide sucrose , commonly known as table sugar, cane sugar, or beet sugar. Sucrose digestion yields the sugars fructose and glucose which are readily absorbed by the small intestine.

Some nutrients are complex molecules for example vitamin B 12 which would be destroyed if they were broken down into their functional groups. To digest vitamin B 12 non-destructively, haptocorrin in saliva strongly binds and protects the B 12 molecules from stomach acid as they enter the stomach and are cleaved from their protein complexes. After the B 12 -haptocorrin complexes pass from the stomach via the pylorus to the duodenum, pancreatic proteases cleave haptocorrin from the B 12 molecules which rebind to intrinsic factor IF.

These B 12 -IF complexes travel to the ileum portion of the small intestine where cubilin receptors enable assimilation and circulation of B 12 -IF complexes in the blood. There are at least five hormones that aid and regulate the digestive system in mammals.

There are variations across the vertebrates, as for instance in birds. Arrangements are complex and additional details are regularly discovered. For instance, more connections to metabolic control largely the glucose-insulin system have been uncovered in recent years. Digestion is a complex process controlled by several factors. In the mouth, pharynx and esophagus, pH is typically about 6. Saliva controls pH in this region of the digestive tract. Salivary amylase is contained in saliva and starts the breakdown of carbohydrates into monosaccharides.

Most digestive enzymes are sensitive to pH and will denature in a high or low pH environment. The stomach's high acidity inhibits the breakdown of carbohydrates within it.

This acidity confers two benefits: In the small intestines, the duodenum provides critical pH balancing to activate digestive enzymes. The liver secretes bile into the duodenum to neutralize the acidic conditions from the stomach, and the pancreatic duct empties into the duodenum, adding bicarbonate to neutralize the acidic chyme , thus creating a neutral environment. The mucosal tissue of the small intestines is alkaline with a pH of about 8.

From Wikipedia, the free encyclopedia. For the industrial process, see anaerobic digestion. For the journal, see Digestion journal. A Catalina Macaw 's seed-shearing beak.

This section needs expansion with: You can help by adding to it. Human Biology and Health. Scientific American Library, New York.

Living at Micro Scale , p. Harvard University Press, Cambridge, Mass. Secretory Mechanisms and Role in Pathogenesis. A Molecular Approach , 2nd ed. Journal of General Microbiology. Inspiration for design of robust organic composites". Levi Publishing Co, Inc. US National Library of Medicine.

US National Institutes of Health. Retrieved 27 June Physiology of the gastrointestinal system. Submucous plexus Myenteric plexus. Segmentation contractions Migrating motor complex Borborygmus Defecation. Retrieved from " https: Pages with unresolved properties CS1 maint: Views Read View source View history.

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